Key result
Inhibition of myosin VI activity by siRNA knockdown increased the rate of multinucleated cells from 3% to 13%, demonstrating its essential role in targeted membrane transport during cytokinesis.
Absolute Event Rate: 13% vs 3%
Myosin VI and its binding partner GIPC play an essential role in targeted membrane transport during cytokinesis and mitosis.
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Animal data link myosin VI to cytokinesis; leaves open relevance to human cardiomyocyte division or therapeutic targeting.
Arden et al. (2007) studied Cytokinesis defects. Myosin VI inhibition (siRNA knockdown) vs. Mock-transfected cells was evaluated on Percentage of multinucleated cells. Inhibition of myosin VI activity by siRNA knockdown increased the rate of multinucleated cells from 3% to 13%, demonstrating its essential role in targeted membrane transport during cytokinesis.
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