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Review discusses the pharmacology and therapeutic potential of (-)-huperzine A for neurodegeneration, suggesting its role in Alzheimer's treatment.
Abstract: (–)-Huperzine A (1) is an alkaloid isolated from a Chinese club moss. Due to its potent neuroprotective activities, it has been investigated as a candidate for the treatment of neurodegenerative diseases, including Alzheimer's disease. In this review, we will discuss the pharmacology and therapeutic potential of (–)-huperzine A (1). Synthetic studies of (–)-huperzine A (1) aimed at enabling its development as a pharmaceutical will be described.
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Herzon et al. (2012) studied this question.
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