Key result
Elevated fractions of CD4+CD28null T cells were independently associated with the development of post-operative atrial fibrillation (adjusted OR 4.89 per 1-SD increase).
Why the study?
Is the fraction of CD4+CD28null T Lymphocytes associated with the development of post-operative atrial fibrillation after elective cardiac surgery?
Population
Patients undergoing elective cardiac surgery
Comparison
Higher fraction of CD4+CD28null T Lymphocytes vs Lower fraction of CD4+CD28null T Lymphocytes
Design
Cohort
Authors
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Elevated CD4+CD28null fractions may flag POAF risk after surgery; leaves open causal role and immunomodulatory prevention.
Cohort (n=129)
No
Is the fraction of CD4+CD28null T Lymphocytes associated with the development of post-operative atrial fibrillation after elective cardiac surgery?
Odds Ratio: 4.89 (95% CI 2.68–8.97)
Absolute Event Rate: 11.1% vs 1.9%
p-value: p=<0.001
The fraction of CD4+CD28null T lymphocytes is a strong independent predictor of post-operative atrial fibrillation after elective cardiac surgery, and its levels may be reduced by pre-operative statin therapy.
Sulzgruber et al. (2018) conducted a cohort in Post-operative atrial fibrillation (POAF) (n=129). CD4+CD28null T Lymphocytes vs. Lower frequencies of CD4+CD28null T Lymphocytes was evaluated on Development of post-operative atrial fibrillation (POAF) (OR 4.89, 95% CI 2.68-8.97, p=<0.001). Elevated fractions of CD4+CD28null T cells were independently associated with the development of post-operative atrial fibrillation (adjusted OR 4.89 per 1-SD increase).
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