Key result
In patients with type 2 diabetes aged over 75 years, most lipid profile indices were not related to all-cause mortality, but each 1 mmol/L higher serum triglyceride level was associated with a 17% decreased risk of mortality.
Why the study?
What is the relationship between the lipid profile over time and mortality in elderly patients with type 2 diabetes mellitus?
Population
881 primary care patients with type 2 diabetes mellitus (T2DM) aged 60 years and older
Design
Cohort
Follow-up
median 9.8 years
Authors
Loading...
May inform age-stratified lipid risk assessment in elderly T2DM; leaves open causality and needs prospective confirmation before practice change.
Observational (n=881)
What is the relationship between the lipid profile over time and mortality in elderly patients with type 2 diabetes mellitus?
Hazard Ratio: 0.83 (95% CI 0.73–0.95)
In elderly patients with T2DM, the relationship between lipid profiles and mortality varies by age and diabetes duration, with higher triglycerides paradoxically associated with lower all-cause mortality in those over 75.
Hateren et al. (2009) conducted an observational in Type 2 diabetes mellitus (n=881). Serum triglyceride levels vs. Lower triglyceride levels was evaluated on All-cause mortality (per 1 mmol/L increase in triglycerides in patients >75 years) (17% decrease in mortality risk, 95% CI 5% to 27%). In patients with type 2 diabetes aged over 75 years, most lipid profile indices were not related to all-cause mortality, but each 1 mmol/L higher serum triglyceride level was associated with a 17% decreased risk of mortality.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: