Key result
The 2-A resolution crystal structure of myosin light chain 1 bound to the IQ2-IQ3 fragment of Myo2p reveals specific cooperative interactions between light chains within each IQ pair.
The structural model of the myosin V light chain-binding domain provides insights into its function, regulation, and molecular interactions, highlighting the noncanonical extended conformation of bound light chains.
No takes yet. Share an insight, caveat, or question.
Should not change clinical practice; leaves open how these interactions regulate mammalian cardiac myosins.
Terrak et al. (2005) studied this question. The 2-A resolution crystal structure of myosin light chain 1 bound to the IQ2-IQ3 fragment of Myo2p reveals specific cooperative interactions between light chains within each IQ pair.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: