Key result
Early onset of obesity (< 20 years) was associated with a significantly lower risk of type 2 diabetes (OR 0.58) and hypertension (OR 0.47) prior to bariatric surgery compared to adult onset.
Why the study?
Does early onset of obesity compared to adult onset affect metabolic parameters and health problems in bariatric surgery candidates?
Observational (n=469)
No
Does early onset of obesity compared to adult onset affect metabolic parameters and health problems in bariatric surgery candidates?
Early onset of obesity is associated with a lower prevalence of hypertension and type 2 diabetes compared to adult onset in bariatric surgery candidates, despite higher BMI.
Suggests age of obesity onset may influence cardiometabolic risk profiles in surgical candidates; leaves open whether.
BACKGROUND: Patients who are slated for bariatric surgery vary in terms of their age at onset of obesity, duration of obesity, and their health complications. Therefore, we aimed to explore a relationship between the age at onset of obesity, metabolic parameters, and health problems in bariatric surgery candidates. METHODS: A total of 469 unrelated adults with obesity prior to bariatric surgery were included in this study. The study group consisted of 246 individuals who became obese < 20 years of age, and 223 individuals who became obese ≥ 20 years. Clinical, biochemical, anthropometric assessments, and DXA-derived measures were taken. RESULTS: than patients with adult onset of obesity (≥ 20 years). Multivariable logistic regression demonstrated that, among bariatric surgery candidates with early onset of obesity, the frequency of hypertension and type 2 diabetes was significantly lower than that in cases with an adult onset of obesity, despite a longer duration of obesity and higher BMI. CONCLUSIONS: The age at which an individual reaches obesity has a significant impact on patient characteristics on the day he or she is evaluated for bariatric surgery. A younger age at obesity onset is a predicting factor for a higher BMI in patients, but they are less likely to clinically manifest well-established consequences of obesity, such as diabetes or hypertension, compared to patients with adult onset of obesity.
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Wrzosek et al. (2018) conducted an observational in Severe obesity prior to bariatric surgery (n=469). Early onset of obesity (< 20 years) vs. Adult onset of obesity (≥ 20 years) was evaluated on Type 2 diabetes (OR 0.58, 95% CI 0.38-0.83, p=0.017). Early onset of obesity (< 20 years) was associated with a significantly lower risk of type 2 diabetes (OR 0.58) and hypertension (OR 0.47) prior to bariatric surgery compared to adult onset.
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