An mRNA structure that controls gene expression by binding FMN
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Implication
Randomized trial demonstrates metabolite-dependent control of gene expression in prokaryotes, suggesting mRNA's role in regulation.
Key Points
- This study aims to investigate how the RFN element in prokaryotic mRNAs regulates gene expression by binding FMN.
- Analyses of sequence and structure of RFN elements in prokaryotic mRNAs.
- Characterization of FMN-binding properties of the RFN element as a riboswitch.
- Examination of the effects on transcription termination in Bacillus subtilis.
- The RFN element binds FMN directly and functions as a natural FMN-binding aptamer.
- In Bacillus subtilis, the riboswitch causes premature transcription termination of the ribDEAHT operon.
- Binding of FMN disrupts access to the ribosome-binding site of ypaA mRNA.
Cite This Study
Winkler et al. (2002) studied this question.