January 1, 2001Cardiology
Prediction of Reversible Myocardial Dysfunction by Positron Emission Tomography, Low-Dose Dobutamine Echocardiography, Resting ECG, and Exercise Testing
Key result
Positron emission tomography (PET) yielded the highest accuracy (80%) and sensitivity (100%) for predicting reversible myocardial dysfunction compared to LDDE, exercise testing, and resting ECG.
Why the study?
Which diagnostic modality (PET, LDDE, resting ECG, or exercise testing) best predicts reversible myocardial dysfunction in heart failure patients undergoing coronary artery bypass grafting?
Population
35 coronary artery bypass graft patients with heart failure and an ejection fraction of 35 +/- 7%
Comparison
Preoperative 18F-fluoro-2-deoxyglucose positron… vs Comparison among the four diagnostic modalities
Design
Cohort
Follow-up
6 months
Authors
Discussion
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Implication
PET/LDDE algorithms may aid HF patient selection for CABG; leaves open prospective outcome validation before clinical adoption.
Study Design
Type
Observational (n=35)
Structured PICO
Which diagnostic modality (PET, LDDE, resting ECG, or exercise testing) best predicts reversible myocardial dysfunction in heart failure patients undergoing coronary artery bypass grafting?
P
Population
35 coronary artery bypass graft patients with heart failure and an ejection fraction of 35 +/- 7%, followed up at 6 months.
E
Exposure
Preoperative 18F-fluoro-2-deoxyglucose positron emission tomography (PET), low-dose dobutamine echocardiography (LDDE), resting ECG, and exercise testing
C
Comparator
Comparison among the four diagnostic modalities (PET, LDDE, resting ECG, and exercise testing)
O
Outcome
Prediction of reversible myocardial dysfunction (assessed by echocardiography and coronary angiography 6 months after coronary artery bypass grafting)surrogate
PET provides the highest overall accuracy (80%) for predicting reversible myocardial dysfunction in heart failure patients undergoing revascularization, and a stepwise approach using exercise testing followed by PET or LDDE may optimize diagnostic yield.
Limitations
- Requires further evaluation in larger patient populations with heart failure
- Small sample size
Cite This Study
Wiggers et al. (2001) conducted an observational in Heart failure (n=35). Positron emission tomography (PET) vs. Low-dose dobutamine echocardiography, resting ECG, and exercise testing was evaluated on Prediction of reversible myocardial dysfunction. Positron emission tomography (PET) yielded the highest accuracy (80%) and sensitivity (100%) for predicting reversible myocardial dysfunction compared to LDDE, exercise testing, and resting ECG.