Key result
In a cohort of 207 children with Kawasaki disease, 87.5% of coronary anomalies completely regressed, while absence of IVIG treatment was associated with a lower regression rate (57.1% vs 92.2%).
Why the study?
The medium to long term prognosis of children with Kawasaki disease remains unclear.
Does treatment with intravenous immunoglobulins improve the regression rate of coronary aneurysms in patients with Kawasaki disease?
Population
207 patients diagnosed with Kawasaki disease between 1981 and 2014
Design
Single-center retrospective medical record review
Authors
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May support IVIG to improve aneurysm regression in Kawasaki disease; hypothesis-generating and requires randomized confirmation.
Cohort (n=207)
No
Does treatment with intravenous immunoglobulins improve the regression rate of coronary aneurysms in patients with Kawasaki disease?
Absolute Event Rate: 92.2% vs 57.1%
p-value: p=0.07
The medium to long-term prognosis after Kawasaki disease is excellent, with high rates of coronary aneurysm regression, though patients not treated with immunoglobulins, boys, and those outside the usual age range are at higher risk for unfavorable outcomes.
Harpe et al. (2019) conducted a cohort in Kawasaki Disease (n=207). Intravenous immunoglobulin (IVIG) vs. No IVIG was evaluated on Regression of coronary artery aneurysms or dilatations (p=0.07). In a cohort of 207 children with Kawasaki disease, 87.5% of coronary anomalies completely regressed, while absence of IVIG treatment was associated with a lower regression rate (57.1% vs 92.2%).
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