Why the study?
Does daily oral vitamin K supplementation improve anticoagulation stability in warfarin-treated patients with unstable control?
Population
70 warfarin-treated patients with unstable anticoagulation control
Comparison
Oral vitamin K 150 mcg daily for 6 months vs Oral placebo daily for 6 months
Design
RCT, randomly assigned, double-blinded fashion
Follow-up
6 months
Key result
Oral vitamin K supplementation significantly decreased the standard deviation of INR compared with placebo (-0.24 vs -0.11; P<.001) in patients with unstable warfarin control.
Authors
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Oral vitamin K improves INR stability in unstable warfarin patients; supports targeted supplementation and further RCTs in this subgroup.
RCT (n=70)
Double-blind
randomly assigned
Does daily oral vitamin K supplementation improve anticoagulation stability in warfarin-treated patients with unstable control?
Absolute Event Rate: -0.24% vs -0.11%
p-value: p=<.001
Low-dose daily oral vitamin K supplementation significantly improves INR stability and time in therapeutic range in patients with previously unstable warfarin anticoagulation.
Sconce et al. (2006) conducted an RCT in Unstable anticoagulation control on warfarin (n=70). Oral vitamin K vs. Placebo was evaluated on Decrease in standard deviation of international normalized ratio (INR) (p=<.001). Oral vitamin K supplementation significantly decreased the standard deviation of INR compared with placebo (-0.24 vs -0.11; P<.001) in patients with unstable warfarin control.