Key result
Patients receiving care at hospitals with low rates of pharmacologic VTE prophylaxis did not have a higher adjusted hazard of 90-day VTE compared to highest-performance hospitals (HR 0.96; 95% CI 0.63-1.45).
Why the study?
Does higher hospital-level performance for pharmacologic VTE prophylaxis reduce the rate of venous thromboembolism in hospitalized general medical patients?
Population
31,260 general medical patients admitted to 35 Michigan hospitals.
Comparison
Care at hospitals in moderate-performance or… vs Care at hospitals in the high-performance…
Design
Cohort
Follow-up
90 days
Authors
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Leaves open whether higher prophylaxis rates reduce hospital VTE in medical patients; prospective trials needed to guide practice.
Cohort (n=31,260)
Yes
Does higher hospital-level performance for pharmacologic VTE prophylaxis reduce the rate of venous thromboembolism in hospitalized general medical patients?
Hazard Ratio: 0.96 (95% CI 0.63–1.45)
Higher hospital-level rates of pharmacologic VTE prophylaxis do not significantly reduce the 90-day hazard of VTE in hospitalized general medical patients.
Flanders et al. (2014) conducted a cohort in Acute medical illness requiring hospitalization (n=31,260). Low or moderate hospital rates of pharmacologic VTE prophylaxis vs. Highest-performance tertile of pharmacologic VTE prophylaxis was evaluated on Time to development of VTE within 90 days of hospital admission (HR 0.96, 95% CI 0.63-1.45). Patients receiving care at hospitals with low rates of pharmacologic VTE prophylaxis did not have a higher adjusted hazard of 90-day VTE compared to highest-performance hospitals (HR 0.96; 95% CI 0.63-1.45).
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