Key result
Large weight loss (> 10%) was associated with a significantly increased risk of all-cause mortality (HR 2.27) and major cardiovascular events (HR 1.71) among patients with type 2 diabetes mellitus.
Why the study?
The prognostic impact of weight loss achieved without behavioural intervention on mortality and cardiovascular outcomes in patients with type 2 diabetes remains contested.
Does weight loss or weight variability affect mortality and cardiovascular events in patients with type 2 diabetes mellitus?
Comparison
Weight loss (>10% vs 5-10%) or weight variability
Design
Systematic review and meta-analysis
Authors
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Warrants clinical vigilance for reverse causality when observing large weight reductions in T2DM; leaves open.
Meta-Analysis (n=207,901)
Does weight loss or weight variability affect mortality and cardiovascular events in patients with type 2 diabetes mellitus?
Hazard Ratio: 2.27 (95% CI 1.51–3.42)
Large unintentional weight loss (>10%) and weight variability in T2DM patients are associated with increased mortality and cardiovascular events, suggesting they may be markers of underlying risk.
Huang et al. (2022) conducted a meta-analysis in Type 2 diabetes mellitus (n=207,901). Large weight loss (> 10%) vs. Reference group (stable weight or <5% weight loss) was evaluated on All-cause mortality (HR 2.27, 95% CI 1.51-3.42). Large weight loss (> 10%) was associated with a significantly increased risk of all-cause mortality (HR 2.27) and major cardiovascular events (HR 1.71) among patients with type 2 diabetes mellitus.
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