Why the study?
Because weight control is central to diabetes management, the study sought to investigate whether weight changes early after diagnosis influence cardiovascular disease incidence and all-cause mortality in patients with type 2 DM.
Does weight change early after diagnosis influence the incidence of cardiovascular disease and all-cause mortality in patients with new-onset type 2 diabetes mellitus?
Population
173,246 subjects with new-onset DM in the Korean National Health Insurance System
Comparison
Five categories of 2-year weight change from weight loss ≥ -10% to weight gain ≥ 10%
Design
Nationwide cohort study
Follow-up
Median 5.5 years
Authors
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Greater than 10% early weight change after new-onset type 2 diabetes was associated with higher mortality and CVD; leaves open whether intentional management alters outcomes.
Does weight change early after diagnosis influence the incidence of cardiovascular disease and all-cause mortality in patients with new-onset type 2 diabetes mellitus?
In patients with new-onset type 2 diabetes, weight changes of more than 10% (both loss and gain) are associated with higher all-cause mortality, and weight gain over 10% increases the risk of stroke.
Kim et al. (2019) studied this question.
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