Key result
Ultra-long duration exercise (a 246 km race) reduced left ventricular global longitudinal strain from -20.9% to -18.8% (p=0.009) and increased left ventricular wall thickness (p<0.001).
Why the study?
The pathophysiological determinants of cardiac changes following ultra-long duration exercise were investigated.
Does ultra-long duration exercise cause echocardiographic and biochemical cardiac changes in runners?
Population
Twenty-seven runners who finished a 246 km running race
Comparison
Before vs after finishing a 246 km running race
Design
Observational cohort study
Authors
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Acute LV wall thickening after ultra-endurance running warrants no practice change; leaves open mechanisms and long-term sequelae.
Observational (n=27)
Does ultra-long duration exercise cause echocardiographic and biochemical cardiac changes in runners?
Absolute Event Rate: -18.8% vs -20.9%
p-value: p=0.009
Ultra-long duration exercise induces transient structural and functional cardiac changes, including increased LV wall thickness and mild RV dilatation with altered systolic function, likely related to altered RV afterload.
Christou et al. (2020) conducted an observational in Ultra-long duration exercise (n=27). Ultra-long duration exercise (246 km running race) vs. Pre-race baseline was evaluated on Left ventricular global longitudinal strain (p=0.009). Ultra-long duration exercise (a 246 km race) reduced left ventricular global longitudinal strain from -20.9% to -18.8% (p=0.009) and increased left ventricular wall thickness (p<0.001).
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