A risk score incorporating clinical and ECG factors yielded a predictive performance of 0.82 for arrhythmic events in Brugada Syndrome, with a score >2 indicating a 9.2% 5-year event probability.
Cohort (n=400)
No
Can a clinical risk score predict long-term arrhythmic events in patients with Brugada Syndrome?
A simple clinical risk score incorporating ECG pattern, family history, EP study results, and clinical presentation can effectively predict long-term arrhythmic events in patients with Brugada Syndrome.
AIMS: Risk stratification in Brugada Syndrome (BS) remains challenging. Arrhythmic events can occur life-long and studies with long follow-ups are sparse. The aim of our study was to investigate long-term prognosis and risk stratification of BS patients. METHODS AND RESULTS: A single centre consecutive cohort of 400 BS patients was included and analysed. Mean age was 41.1 years, 78 patients (19.5%) had a spontaneous type I electrocardiogram (ECG). Clinical presentation was aborted sudden cardiac death (SCD) in 20 patients (5.0%), syncope in 111 (27.8%) and asymptomatic in 269 (67.3%). Familial antecedents of SCD were found in 184 individuals (46.0%), in 31 (7.8%) occurred in first-degree relatives younger than 35 years. An implantable cardioverter defibrillator (ICD) was placed in 176 (44.0%). During a mean follow-up of 80.7 months, 34 arrhythmic events occurred (event rate: 1.4% year). Variables significantly associated to events were: presentation as aborted SCD (Hazard risk HR 20.0), syncope (HR 3.7), spontaneous type I (HR 2.7), male gender (HR 2.7), early SCD in first-degree relatives (HR 2.9), SND (HR 5.0), inducible VA (HR 4.7) and proband status (HR 2.1). A score including ECG pattern, early familial SCD antecedents, inducible electrophysiological study, presentation as syncope or as aborted SCD and SND had a predictive performance of 0.82. A score greater than 2 conferred a 5-year event probability of 9.2%. CONCLUSIONS: BS patients remain at risk many years after diagnosis. Early SCD in first-degree relatives and SND are risk factors for arrhythmic events. A simple risk score might help in the stratification and management of BS patients.
Sieira et al. (2017) conducted a cohort in Brugada Syndrome (n=400). Clinical and electrocardiographic risk factors was evaluated on Arrhythmic events. A risk score incorporating clinical and ECG factors yielded a predictive performance of 0.82 for arrhythmic events in Brugada Syndrome, with a score >2 indicating a 9.2% 5-year event probability.