Key result
A multiparametric risk score predicted future arrhythmic events in Brugada syndrome, with event rates of 0%, 4%, and 60% among patients with 0-1, 2-3, and 4-5 risk factors, respectively (P<0.001).
Why the study?
Risk stratification in Brugada syndrome remains an unsettled clinical issue.
Does a multiparametric risk stratification approach predict future arrhythmic events in patients with Brugada syndrome without previous cardiac arrest?
Cohort (n=111)
Yes
Does a multiparametric risk stratification approach predict future arrhythmic events in patients with Brugada syndrome without previous cardiac arrest?
Absolute Event Rate: 60% vs 0%
p-value: p=<0.001
A multiparametric risk score including clinical, ECG, and EPS factors effectively stratifies the risk of future arrhythmic events in patients with Brugada syndrome.
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Supports risk stratification in Brugada syndrome; leaves open impact on ICD decisions pending validation.
Letsas et al. (2019) conducted a cohort in Brugada syndrome (n=111). Multiparametric risk factors vs. 0-1 risk factor was evaluated on Future arrhythmic events (p=<0.001). A multiparametric risk score predicted future arrhythmic events in Brugada syndrome, with event rates of 0%, 4%, and 60% among patients with 0-1, 2-3, and 4-5 risk factors, respectively (P<0.001).
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