Key result
Serum induced both matrix metalloproteinase (MMP) and tissue inhibitor of metalloproteinases (TIMP) expression at the mRNA and protein levels in a dose-dependent manner in human heart cells.
Serum induces proliferation and dose-dependent expression of MMP and TIMP in human heart-derived fibroblast and endothelial cells, regulated at transcriptional and translational levels.
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Hypothesis-generating for serum regulation of cardiac matrix turnover in vitro; leaves open in vivo translation and clinical relevance.
Tyagi et al. (1995) studied this question. Serum vs. Serum-free medium was evaluated on MMP and TIMP expression at mRNA and protein levels. Serum induced both matrix metalloproteinase (MMP) and tissue inhibitor of metalloproteinases (TIMP) expression at the mRNA and protein levels in a dose-dependent manner in human heart cells.
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