Key result
Therapeutic-dose tinzaparin for 5 days in 32 patients with varying renal function did not result in accumulation of anticoagulant effects, with only 1 patient requiring dose adjustment.
Why the study?
Does therapeutic-dose tinzaparin cause accumulation of anticoagulant effects in patients with varying degrees of renal insufficiency?
Population
32 in- and out-patients requiring therapeutic dose anticoagulation for the initial treatment of venous…
Design
Cohort
Follow-up
5 days
Authors
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Tinzaparin showed no anti-Xa accumulation in renal impairment; leaves open whether this supports broader use without monitoring in severe CKD.
Cohort (n=32)
Does therapeutic-dose tinzaparin cause accumulation of anticoagulant effects in patients with varying degrees of renal insufficiency?
A 5-day course of therapeutic-dose tinzaparin does not appear to accumulate in patients with renal insufficiency, including those on hemodialysis.
Lim et al. (2005) conducted a cohort in Venous thromboembolism (VTE) with renal insufficiency (n=32). Tinzaparin was evaluated on Anti-Xa levels correlated with renal function. Therapeutic-dose tinzaparin for 5 days in 32 patients with varying renal function did not result in accumulation of anticoagulant effects, with only 1 patient requiring dose adjustment.
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