Why the study?
What are the population pharmacodynamic parameters of tinzaparin in patients receiving it for the prevention and treatment of deep vein thrombosis?
Population
425 patients participating in 2 Phase III clinical studies for the treatment of deep vein thrombosis or…
Comparison
Tinzaparin vs Heparin or enoxaparin 40 mg once daily
Design
Other, randomized, double-blind
Authors
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Clearance reductions suggest dosing caution in severe renal impairment or obesity; extends tinzaparin population PK data to these groups.
What are the population pharmacodynamic parameters of tinzaparin in patients receiving it for the prevention and treatment of deep vein thrombosis?
Tinzaparin exhibits similar pharmacodynamics in patients with DVT or undergoing hip replacement as in healthy volunteers, supporting weight-based dosing.
Barrett et al. (2009) studied this question.