Why the study?
Does tinzaparin have favorable pharmacodynamics and bioavailability compared to unfractionated heparin in healthy men?
Population
30 healthy men
Comparison
Tinzaparin sodium vs Unfractionated heparin 5,000 units s.c.
Design
RCT, Randomized, five-treatment, five-period-crossover study with a Latin…
Follow-up
24 hours
Authors
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Supports tinzaparin for more predictable anticoagulation than heparin; extends PK evidence to guide LMWH dosing strategies.
Does tinzaparin have favorable pharmacodynamics and bioavailability compared to unfractionated heparin in healthy men?
Subcutaneous tinzaparin is well absorbed with high bioavailability and demonstrates lower intersubject pharmacodynamic variability compared to standard unfractionated heparin.
Fossler et al. (2001) studied this question.
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