Why the study?
What are the pharmacodynamic properties of tinzaparin given as a single daily administration in healthy volunteers?
Population
14 healthy volunteers
Design
Other
Follow-up
5 days
Authors
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Should not yet change LMWH monitoring; leaves open whether anti-Xa or APTT predicts outcomes in patients.
What are the pharmacodynamic properties of tinzaparin given as a single daily administration in healthy volunteers?
The antithrombotic and prohaemorrhagic effects of low molecular weight heparins appear independent of absolute antifactor Xa activity levels and APTT prolongation.
Cambus et al. (2002) studied this question.
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