Key result
Treatment with low molecular weight heparin in 30 pregnant women with late second trimester oligohydramnios resulted in 28 live births and significant improvement in amniotic fluid index in 26 patients.
Why the study?
The study was conducted to evaluate the efficacy of low molecular weight heparin in late second trimester oligohydramnios cases.
Does low molecular weight heparin improve amniotic fluid index and fetal outcomes in pregnant patients with late second trimester oligohydramnios?
Does low molecular weight heparin improve amniotic fluid index and fetal outcomes in pregnant patients with late second trimester oligohydramnios?
Low molecular weight heparin may improve amniotic fluid index and fetal outcomes in pregnancies complicated by late second trimester oligohydramnios, though larger studies are needed.
Answers are grounded in this paper and cite their sources.
LMWH may improve oligohydramnios outcomes; leaves open causal benefit pending randomized confirmation.
Objective: To find out low molecular weight heparin (LMWH) efficacy inlate second trimester oligohydramnios cases. Study Design: Quasi-experimental study. Place and Duration of Study: Combined Military Hospital Malir, from Jan to Jun 2017. Methodology: A total of 30 patients having amniotic fluid index (AFI) <8 on ultrasound scan during their late second trimester phase were enrolled in the study after informed consent. Exclusion criteria included congenital anomalies on U/S, PPROM, and drug-induced oligohydramnios. Personal, medical and obstetric history was obtained for age, parity and co-morbids like hypertension, antiphospholipid syndrome, and previous oligohydramnios. Low molecular weight heparin was started at dose of 0.5mg/kg of body weight subcutaneously for 8-12 weeks and stopped 24 hours prior to delivery. Rescan for amniotic fluid index and fetal bio-metry assessment done every 2 weeks till date of delivery. Fetal outcome in terms of maturity, mode of delivery, birth weight, APGAR score and need for NICU admission were measured. Results: There were 28 live births and two intrauterine deaths. Twelve patients were delivered normally and 18 had elective LSCS. Of twenty eight cases, eight were premature low birth weight (LBW) babies. Twenty six patients showed significant improvement in amniotic fluid index. Average birth weight was 2.5kg. Neonates showed an average APGAR score of 7. Eight neonates admitted in NICU (for prematurity and/or low birth weight) and discharged within a week. Conclusion: Low molecular weight heparin plays significant role in treating oligohydramnios in cases with or without risk factors. However further studies with large sample............
No takes yet. Share an insight, caveat, or question.
Iftikhar et al. (2021) studied Late second trimester oligohydramnios (n=30). Low molecular weight heparin (LMWH) was evaluated on Live births. Treatment with low molecular weight heparin in 30 pregnant women with late second trimester oligohydramnios resulted in 28 live births and significant improvement in amniotic fluid index in 26 patients.
Synapse has enriched 10 related papers. Consider them for comparative context: