What question did this study set out to answer?

This research investigates the potential association between angiotensin receptor blockers (ARBs) and cancer risk, focusing on overall cancer incidence and specific types.

April 12, 2011CirculationOpen Access

Use of Angiotensin Receptor Blockers and the Risk of Cancer

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: New users of ARBs and ACE inhibitors (n=317158). Intervention: Angiotensin Receptor Blockers (ARBs) vs. Angiotensin-converting enzyme (ACE) inhibitors. Primary outcome: Incident cancer (RR 0.99, 95% CI 0.95-1.03).

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Key result

Use of ARBs was not significantly associated with an increased risk of incident cancer compared with ACE inhibitors (RR 0.99; 95% CI 0.95-1.03).

Why the study?

Does the use of angiotensin receptor blockers increase the risk of incident cancer compared to ACE inhibitors in adults?

Population

317,158 adults who were new users of angiotensin receptor blockers or angiotensin-converting enzyme…

Comparison

Angiotensin receptor blockers (ARBs) vs Angiotensin-converting enzyme (ACE) inhibitors

Design

Cohort

Follow-up

312,753 person-years for ARB users and 435,207…

Authors

BPBjörn PasternakHeart Failure / Cardiomyopathy HSHenrik SvanströmStatens Serum Institut TCTorbjörn CallréusHeritage Malta

Discussion

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Implication

No increased cancer risk observed with ARBs; leaves open a possible modest association.

Key Points

This research investigates the potential association between angiotensin receptor blockers (ARBs) and cancer risk, focusing on overall cancer incidence and specific types.
Linked individual-level data from Danish registries on drug prescriptions and diagnostic information.
Compared cancer incidence rates among 107,466 ARB users and 209,692 angiotensin-converting enzyme inhibitor users over 312,753 person-years follow-up.
Conducted subgroup analyses for different cancer types, particularly lung cancer and male genital organ cancers.
Among ARB users, 3,954 cancer cases were reported compared to 6,214 cases in ACE inhibitor users with an adjusted rate ratio of 0.99 (95% CI 0.95 to 1.03).
There was no increase in cancer risk with longer ARB usage; the increase in rate ratio per year was 0.99 (95% CI 0.99 to 1.00).
A significant association was found between ARB use and cancer of male genital organs (rate ratio 1.15, 95% CI 1.02 to 1.28), but not for the overall lung cancer risk (rate ratio 0.92, 95% CI 0.82 to 1.02).

Study Design

Type

Cohort (n=317,158)

Multicenter

Yes

Structured PICO

Does the use of angiotensin receptor blockers increase the risk of incident cancer compared to ACE inhibitors in adults?

Population

317,158 new users of ARBs and ACE inhibitors aged ≥35 years in Denmark, evaluated for incident cancer risk.

Exposure

Angiotensin receptor blockers (ARBs)

Comparator

Angiotensin-converting enzyme (ACE) inhibitors

Outcome

Incidence rates of all cancersafety

Main Result

Relative Risk: 0.99 (95% CI 0.95–1.03)

Absolute Event Rate: 3.68% vs 2.96%

In a large nationwide Danish cohort, the use of ARBs was not associated with an increased risk of incident cancer overall or lung cancer compared to ACE inhibitors, reassuring their safety profile.

Cite This Study

Pasternak et al. (2011) conducted a cohort in New users of ARBs and ACE inhibitors (n=317,158). Angiotensin Receptor Blockers (ARBs) vs. Angiotensin-converting enzyme (ACE) inhibitors was evaluated on Incident cancer (RR 0.99, 95% CI 0.95-1.03). Use of ARBs was not significantly associated with an increased risk of incident cancer compared with ACE inhibitors (RR 0.99; 95% CI 0.95-1.03).

synapsesocial.com/papers/6a5e79f467fd328bf6efebf9 https://doi.org/10.1161/circulationaha.110.007336

Topics

Women and heart disease

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Use of Angiotensin Receptor Blockers and the Risk of Cancer

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Topics

Use of Angiotensin Receptor Blockers and the Risk of Cancer

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Topics

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