Key result
Electronic nicotine delivery systems and heated tobacco products cause respiratory damage involving both conventional cigarette pathways and novel mechanisms.
Why the study?
Electronic nicotine delivery systems and heated tobacco products are promoted as safer alternatives without regulations or warnings, prompting a review of their adverse respiratory effects.
Do electronic nicotine delivery systems and heated tobacco products cause adverse respiratory effects in experimental models?
Systematic Review (n=79)
Do electronic nicotine delivery systems and heated tobacco products cause adverse respiratory effects in experimental models?
This systematic review suggests that ENDS and HTP cause respiratory damage through both known and novel mechanisms, challenging industry claims of safety.
Supports clinical caution against ENDS and HTP use; confirms respiratory damage via both conventional and novel mechanisms.
The tobacco industry promotes electronic nicotine delivery systems (ENDS) and heated tobacco products (HTP) as a safer alternative to conventional cigarettes with misleading marketing sustained by studies with conflict of interest. As a result, these devices sell without regulations and warnings about their adverse effects on health, with a growing user base targeting young people. This systematic review aimed to describe the adverse effects on the respiratory system in consumers of these devices. We conducted a systematic review and bibliometric analysis of 79 studies without conflict of interest evaluating ENDS and HTP effects in the respiratory system in experimental models, retrieved from the PubMed database. We found that the damage produced by using these devices is involved in pathways related to pulmonary diseases, involving mechanisms previously reported in conventional cigarettes as well as new mechanisms particular to these devices, which challenges that the tobacco industry's claims. The present study provides significant evidence to suggest that these devices are an emerging public health problem and that they should be regulated or avoided.
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Bravo-Gutiérrez et al. (2021) conducted a systematic review in Respiratory system damage (n=79). Electronic nicotine delivery systems (ENDS) and heated tobacco products (HTP) was evaluated on Adverse effects on the respiratory system. Electronic nicotine delivery systems and heated tobacco products cause respiratory damage involving both conventional cigarette pathways and novel mechanisms.
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