Key result
Glucocorticoid therapy significantly decreased forearm blood flow responses to reactive hyperemia to 43% compared to 130% before therapy, an effect almost normalized by vitamin C.
Why the study?
Does glucocorticoid excess induce vascular endothelial dysfunction through reactive oxygen species production?
Observational (n=20)
Does glucocorticoid excess induce vascular endothelial dysfunction through reactive oxygen species production?
Absolute Event Rate: 43% vs 130%
Glucocorticoid excess causes vascular endothelial dysfunction by inducing reactive oxygen species overproduction and reducing nitric oxide availability.
No takes yet. Share an insight, caveat, or question.
GC therapy may impair endothelial function; leaves open whether antioxidants mitigate vascular risk in exposed patients.
Iuchi et al. (2003) conducted an observational in Glucocorticoid-treated patients (n=20). Glucocorticoid therapy vs. Before glucocorticoid therapy was evaluated on Responses in forearm blood flow to reactive hyperemia. Glucocorticoid therapy significantly decreased forearm blood flow responses to reactive hyperemia to 43% compared to 130% before therapy, an effect almost normalized by vitamin C.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: