Key result
Dexamethasone significantly increased the heart weight to body weight ratio compared to control (3.87 vs 2.83 mg/g, p<0.001) and altered the expression of calcium cycling proteins.
Population
Male Sprague-Dawley rats and neonatal rat ventricular cardiomyocytes from 2-day-old pups
Comparison
Dexamethasone 35 mg/100 g body weight orally… vs Vehicle control
Design
Preclinical
Follow-up
15 days (in vivo), 24 hours (in vitro)
Authors
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Supports glucocorticoid cardiotoxicity via hypertrophy and calcium dysregulation in rodents; hypothesis-generating for human translation.
Absolute Event Rate: 3.87% vs 2.83%
p-value: p=<0.001
Excess glucocorticoid induces cardiac hypertrophy and alters calcium signaling in cardiomyocytes, providing a potential mechanism for glucocorticoid-induced cardiac dysfunction.
De et al. (2011) studied Glucocorticoid-induced myocardial remodeling (n=60). Dexamethasone vs. Vehicle control was evaluated on Heart weight to body weight (HW/BW) ratio (p=<0.001). Dexamethasone significantly increased the heart weight to body weight ratio compared to control (3.87 vs 2.83 mg/g, p<0.001) and altered the expression of calcium cycling proteins.
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