Key result
Dexamethasone increased the heart weight to body weight ratio (P<0.001) and induced cardiac remodeling, which were reversed by mifepristone and losartan.
Authors
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Does not alter glucocorticoid prescribing; hypothesis-generating for receptor and RAAS blockade in steroid cardiomyopathy.
p-value: p=<0.001
Roy et al. (2009) studied Glucocorticoid-induced cardiac dysfunction. Dexamethasone with or without mifepristone or losartan vs. Control / Dexamethasone alone was evaluated on Cardiac remodelling, fibrosis, oxidative stress, and hemodynamic parameters (p=<0.001). Dexamethasone increased the heart weight to body weight ratio (P<0.001) and induced cardiac remodeling, which were reversed by mifepristone and losartan.
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