What does this research mean for the field?

Glucocorticoid administration increases vascular AT1A receptor mRNA expression in vivo, preceding and contributing to the development of glucocorticoid-induced hypertension. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

Determine whether dexamethasone-induced modulation of vascular angiotensin II type 1 (AT1) receptor mRNA expression contributes to glucocorticoid-induced hypertension.

May 1, 1994Journal of Hypertension

Increased expression of vascular angiotensin II type 1A receptor gene in glucocorticoid-induced hypertension

Q: What is the clinical evidence from this study?

Study design: Other. Population: Glucocorticoid-induced hypertension. Intervention: Dexamethasone (with or without enalapril maleate) vs. Enalapril maleate alone / baseline. Primary outcome: Vascular AT1 receptor mRNA expression and blood pressure.

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Key result

Dexamethasone administration in rats increased vascular AT1A receptor mRNA expression starting on day 2, preceding a significant rise in systolic blood pressure on day 5.

Authors

ASAtsuhisa SatoInternational University of Health and Welfare HSHiromichi SuzukiYamagata University YNYuichi NAKAZATONippon Institute of Technology

Discussion

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Implication

Dexamethasone-induced AT1A upregulation precedes BP rise in rats; hypothesis-generating and should not change practice.

Key Points

Determine whether dexamethasone-induced modulation of vascular angiotensin II type 1 (AT1) receptor mRNA expression contributes to glucocorticoid-induced hypertension.
Administered oral dexamethasone (0.1 mg/day) to rats to assess changes in systolic blood pressure and vascular AT1 receptor mRNA expression via Northern blot analysis.
Evaluated the hemodynamic and molecular effects of co-administering the angiotensin-converting enzyme inhibitor enalapril maleate, as well as enalapril maleate alone.
Systolic blood pressure began rising on day 3 and reached statistical significance by day 5 in dexamethasone-treated rats.
Vascular AT1A receptor mRNA levels, which were barely detectable at baseline, increased on day 2 prior to blood pressure elevation and increased further on day 5.
Concurrent administration of enalapril maleate attenuated the blood pressure rise but did not prevent dexamethasone-induced upregulation of AT1A receptor mRNA on days 2 and 5.

PICO

Population

Glucocorticoid-induced hypertension

Intervention / Comparator

Dexamethasone (with or without enalapril maleate) vs Enalapril maleate alone / baseline (0.1 mg/day)

Primary Outcome

Vascular AT1 receptor mRNA expression and blood pressure

Cite This Study

Sato et al. (1994) studied Glucocorticoid-induced hypertension. Dexamethasone (with or without enalapril maleate) vs. Enalapril maleate alone / baseline was evaluated on Vascular AT1 receptor mRNA expression and blood pressure. Dexamethasone administration in rats increased vascular AT1A receptor mRNA expression starting on day 2, preceding a significant rise in systolic blood pressure on day 5.

synapsesocial.com/papers/6a15ccd3a2352da34782eca8 https://doi.org/10.1097/00004872-199405000-00003

Topics

Hypertension management

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Increased expression of vascular angiotensin II type 1A receptor gene in glucocorticoid-induced hypertension

Discussion

Member takes

Implication

Key Points

PICO

Cite This Study

Topics

Increased expression of vascular angiotensin II type 1A receptor gene in glucocorticoid-induced hypertension

Discussion

Member takes

Implication

Key Points

PICO

Cite This Study

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