Key result
Children with hypertrophic cardiomyopathy had significantly reduced systolic deformation compared with controls, which correlated inversely with wall thickness (r=-0.86, P<0.001).
Why the study?
Is regional systolic deformation reduced in pediatric patients with hypertrophic cardiomyopathy and does it correlate with wall thickness and exercise capacity?
Population
41 children with asymmetric hypertrophic cardiomyopathy (mean age 12.3 years) and 29 controls
Comparison
Ultrasonic strain rate imaging vs Healthy controls
Design
Case-control
Authors
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Strain rate imaging may detect regional dysfunction in paediatric HCM; leaves open its clinical utility and prognostic role.
Case-Control (n=70)
Is regional systolic deformation reduced in pediatric patients with hypertrophic cardiomyopathy and does it correlate with wall thickness and exercise capacity?
In children with hypertrophic cardiomyopathy, regional systolic deformation is significantly reduced and correlates with both maximal wall thickness and decreased exercise capacity.
Ganame et al. (2007) conducted a case-control in Hypertrophic cardiomyopathy (n=70). Hypertrophic cardiomyopathy vs. Controls was evaluated on Regional systolic deformation (peak systolic strain rate and strain). Children with hypertrophic cardiomyopathy had significantly reduced systolic deformation compared with controls, which correlated inversely with wall thickness (r=-0.86, P<0.001).
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