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May 11, 2022Advanced Drug Delivery ReviewsOpen Access

Organ-specific endothelial cell heterogenicity and its impact on regenerative medicine and biomedical engineering applications

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Authors

MUMax UrbanczykSwiss Federal Laboratories for Materials Science and TechnologyAZAline ZbindenLeiden University Medical CenterKSKatja Schenke‐LaylandNatural and Medical Sciences Institute

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Overview

Review highlights endothelial cell heterogenicity in different organs, suggesting improvements for in vitro models.

Key Points

  • This review aims to elucidate the phenotypic heterogenicity of endothelial cells across various organs and their implications for regenerative medicine.
  • Reviewed literature on endothelial cell characteristics and their roles in health and disease.
  • Analyzed various in vitro models that neglect endothelial cell heterogenicity.
  • Introduced co-culture test systems for studying brain, pancreas, and liver endothelial functions.
  • Identified significant differences in endothelial cell types across major vascular structures and organ capillaries.
  • Emphasized the need for improved in vitro models to better replicate endothelial cell behaviors in organ-specific contexts.
  • Highlighted future directions to enhance the utility of endothelial cells in biomedical engineering applications.

Cite This Study

Urbanczyk et al. (2022) studied this question.

synapsesocial.com/papers/6a5e8bb34b5cbccdc3065602https://doi.org/10.1016/j.addr.2022.114323
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