Key result
Obesity is not linked to increased in-hospital mortality after CABG for acute coronary syndrome.
Why the study?
Although perioperative care has improved CABG outcomes, obesity can elevate postoperative complication rates and increase morbidity and mortality.
Does obesity increase early in-hospital mortality in patients with acute coronary syndrome undergoing coronary artery bypass grafting?
Cohort (n=1,375)
No
Does obesity increase early in-hospital mortality in patients with acute coronary syndrome undergoing coronary artery bypass grafting?
Obesity does not independently worsen early in-hospital mortality for patients with ACS undergoing CABG, supporting the procedure's safety in overweight populations.
Obesity was not associated with higher in-hospital mortality after CABG in ACS; leaves open whether this holds in prospective or longer-term studies.
Recent advances in perioperative care have considerably improved outcomes after coronary artery bypass graft (CABG) surgery. However, obesity can increase postoperative complication rates and can lead to increased morbidity and mortality. Between June 2011 and October 2019, a total of 1375 patients with acute coronary syndrome (ACS) underwent cardiac surgery and were retrospectively analyzed. Patients were divided into 2 groups: non-obese (body mass index (BMI) < 30 kg/m2, n = 967) and obese (BMI ≥ 30 kg/m2, n = 379). Underweight patients (n = 29) were excluded from the analysis. To compare the unequal patient groups, a propensity score-based matching (PSM) was applied (non-obese group (n = 372) vs. obese group (n = 372)). The mean age of the mentioned groups was 67 ± 10 (non-obese group) vs. 66 ± 10 (obese group) years, p = 0.724. All-cause in-hospital mortality did not significantly differ between the groups before PSM (p = 0.566) and after PSM (p = 0.780). The median length of ICU (p = 0.306 before PSM and p = 0.538 after PSM) and hospital stay (p = 0.795 before PSM and p = 0.131 after PSM) was not significantly higher in the obese group compared with the non-obese group. No significant differences regarding further postoperative parameters were observed between the unadjusted and the adjusted group. Obesity does not predict increased all-cause in-hospital mortality in patients undergoing CABG procedure. Therefore, CABG is a safe procedure for overweight patients.
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Krasivskyi et al. (2022) conducted a cohort in Acute coronary syndrome requiring coronary artery bypass grafting (n=1,375). Obesity (BMI ≥ 30 kg/m2) vs. Non-obese (BMI 18.5-29.9 kg/m2) was evaluated on All-cause in-hospital mortality (p=0.780). Obesity did not significantly increase all-cause in-hospital mortality compared to non-obese patients undergoing coronary artery bypass grafting for acute coronary syndrome.
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