Key result
Obesity was not associated with an increased risk of in-hospital mortality compared to non-obese patients undergoing isolated coronary artery bypass grafting.
Why the study?
Does obesity increase in-hospital mortality and morbidity in patients undergoing isolated CABG?
Cohort (n=13,115)
No
Does obesity increase in-hospital mortality and morbidity in patients undergoing isolated CABG?
In patients undergoing isolated CABG, obesity is associated with increased postoperative respiratory failure, renal failure, and surgical site infections, but not with increased in-hospital mortality.
Answers are grounded in this paper and cite their sources.
May reassure on mortality risk in obese isolated CABG patients; leaves open targeted morbidity mitigation research.
BACKGROUND: There is conflicting data regarding the impact of obesity on morbidity and mortality in patients undergoing isolated coronary artery bypass grafting (CABG). METHODS AND RESULTS: Retrospective cohort analysis of patients who underwent CABG from January 1, 1995, through July 31, 2010 was performed. Patients were classified as obese or non-obese (body mass index ≥ 30.0 kg/m(2) and <30.0 kg/m(2), respectively). The primary outcome was in-hospital mortality. Secondary outcomes included postoperative respiratory failure, postoperative stroke, postoperative myocardial infarction, sternal and leg wound infections, postoperative atrial fibrillation, postoperative ventricular tachycardia, postoperative renal failure and length of hospital stay. Propensity-matched stepwise multivariable logistic regression was performed. Of 13,115 patients, 4,619 (35.2%) were obese. In the propensity-matched logistic regression models (n = 8,442), obesity was not associated with postoperative mortality (odds ratio = 1.13, 95% confidence interval 0.86-1.48). However, obesity was associated with postoperative respiratory failure, postoperative renal insufficiency, sternal wound infection, and leg wound infection. Obesity was also associated with a decreased risk of postoperative bleeding and re-operation from bleeding. CONCLUSIONS: Obesity was associated with an increased risk of postoperative respiratory failure, postoperative renal failure, and surgical site infections. However, obesity was not associated with in-hospital mortality in patients undergoing CABG.
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Alam et al. (2011) conducted a cohort in Coronary artery disease requiring isolated coronary artery bypass grafting (n=13,115). Obesity (BMI ≥30.0 kg/m2) vs. Non-obese (BMI <30.0 kg/m2) was evaluated on In-hospital mortality (OR 1.13, 95% CI 0.86-1.48). Obesity was not associated with an increased risk of in-hospital mortality compared to non-obese patients undergoing isolated coronary artery bypass grafting.
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