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January 1, 2011Circulation JournalOpen Access

Isolated Coronary Artery Bypass Grafting in Obese Individuals - A Propensity Matched Analysis of Outcomes -

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Key result

Obesity was not associated with an increased risk of in-hospital mortality compared to non-obese patients undergoing isolated coronary artery bypass grafting (OR 1.13, 95% CI 0.86-1.48).

Why the study?

Does obesity increase in-hospital mortality and morbidity in patients undergoing isolated CABG?

Population

13,115 patients who underwent isolated coronary artery bypass grafting from January 1, 1995, through July…

Comparison

Obesity (body mass index ≥ 30.0 kg/m2) vs Non-obese (body mass index < 30.0 kg/m2)

Design

Cohort

Follow-up

in-hospital

Authors

MAMahboob AlamRiphah International UniversitySSSahar SiddiquiBaylor College of MedicineVLVei-Vei LeeHouston Methodist

Discussion

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Member takes

Overview

May reassure on mortality risk in obese isolated CABG patients; leaves open targeted morbidity mitigation research.

Study Design

Type

Cohort (n=13,115)

Multicenter

No

Structured PICO

Does obesity increase in-hospital mortality and morbidity in patients undergoing isolated CABG?

P
Population
13,115 patients undergoing isolated coronary artery bypass grafting, retrospectively analyzed to compare in-hospital outcomes between obese and non-obese individuals.
E
Exposure
Obesity (body mass index ≥ 30.0 kg/m2)
C
Comparator
Non-obese (body mass index < 30.0 kg/m2)
O
Outcome
In-hospital mortality (defined as death during hospitalization for CABG surgery)hard clinical

Main Result

Odds Ratio: 1.13 (95% CI 0.86–1.48)

Absolute Event Rate: 2.97% vs 3.66%

In patients undergoing isolated CABG, obesity is associated with increased postoperative respiratory failure, renal failure, and surgical site infections, but not with increased in-hospital mortality.

Limitations

  • Single, tertiary-care referral center experience, which may introduce referral bias
  • Potential for residual confounding not accounted for by propensity-score matching
  • Use of BMI as a surrogate marker for obesity, which may not accurately reflect body fat content or truncal obesity
  • Retrospective chart review design with potential for incomplete data capture and systematic or recorder bias
  • Single, tertiary-care referral center (referral bias)
  • Residual confounding despite propensity matching
  • Use of BMI as a surrogate marker for obesity instead of waist circumference or waist-to-hip ratio
  • Retrospective chart review (incomplete data capture, systematic or recorder bias)

Cite This Study

Alam et al. (2011) conducted a cohort in Coronary artery disease requiring isolated coronary artery bypass grafting (n=13,115). Obesity (BMI ≥30.0 kg/m2) vs. Non-obese (BMI <30.0 kg/m2) was evaluated on In-hospital mortality (OR 1.13, 95% CI 0.86-1.48). Obesity was not associated with an increased risk of in-hospital mortality compared to non-obese patients undergoing isolated coronary artery bypass grafting (OR 1.13, 95% CI 0.86-1.48).

synapsesocial.com/papers/6a9ddaeebf2d38c308a61d45https://doi.org/10.1253/circj.cj-10-1129
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Risk of morbidity and in-hospital mortality in obese patients undergoing coronary artery bypass surgery2002 · 129 citations
  2. 2Severe obesity does not adversely affect perioperative mortality and morbidity in coronary artery bypass surgery2001 · 114 citations
  3. 3The Influence of Obesity on Perioperative Morbidity: Retrospective Study of 502 Aortocoronary Bypass Operations1992 · 108 citations
  4. 4Is Obesity a Risk Factor for Mortality in Coronary Artery Bypass Surgery?2005 · 103 citations
  5. 5Is Extreme Obesity a Risk Factor for Increased In-Hospital Mortality and Postoperative Morbidity after Cardiac Surgery? Results of 2251 Obese Patients with BMI of 30 to 502007 · 31 citations