Key result
Untreated hypercholesterolemia was associated with a blunted postischemic forearm blood flow increase (211%) compared with normocholesterolemic controls (411%) and treated patients (365%, P<0.01).
Why the study?
Does simvastatin improve postischemic blood flow response in hypercholesterolemic patients?
Population
51 subjects including 15 newly diagnosed hypercholesterolemic patients, 15 age- and sex-matched…
Comparison
Simvastatin 10 to 20 mg/d for 2 years vs Untreated hypercholesterolemic patients and…
Design
Cross-sectional
Authors
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Untreated hypercholesterolemia blunts forearm postischemic flow; leaves open whether prolonged statin therapy restores resistance vessel reactivity.
Cross-Sectional (n=51)
Does simvastatin improve postischemic blood flow response in hypercholesterolemic patients?
Absolute Event Rate: 211% vs 411%
p-value: p=<0.01
Prolonged lipid-lowering therapy with simvastatin restores the blunted postischemic blood flow response in resistance vessels of hypercholesterolemic patients.
Hayoz et al. (1995) conducted a cross-sectional in Hypercholesterolemia (n=51). Untreated hypercholesterolemia vs. Normocholesterolemic controls and statin-treated hypercholesterolemic patients was evaluated on Forearm blood flow increase after a 5-minute upper arm occlusion (p=<0.01). Untreated hypercholesterolemia was associated with a blunted postischemic forearm blood flow increase (211%) compared with normocholesterolemic controls (411%) and treated patients (365%, P<0.01).
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