Why the study?
Does hypercholesterolemia alter the peripheral large artery constriction response to an acute low-flow state?
Population
43 male subjects (16 normocholesterolemic and 27 hypercholesterolemic) of similar age and body mass index
Comparison
Acute induction of a low-flow state via wrist… vs Normocholesterolemic male subjects undergoing…
Design
Cross-sectional
Authors
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Hypercholesterolemia may enhance low-flow large-artery constriction; leaves open its role in atherosclerosis progression and requires prospective validation.
Does hypercholesterolemia alter the peripheral large artery constriction response to an acute low-flow state?
Hypercholesterolemia is associated with abnormal, enhanced constriction of peripheral large arteries in response to acute low-flow states, which correlates with the degree of LDL cholesterol elevation.
Filitti et al. (1991) studied this question.
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