Key result
Hypertrophic cardiomyopathy was associated with significantly reduced left atrial total emptying fraction compared to controls (30% vs 42%; P<0.0001) as assessed by cardiac computed tomography.
Why the study?
Can cardiac computed tomography-derived analysis of simultaneous LV and LA volume changes assess diastolic function in patients with hypertrophic cardiomyopathy compared to age-matched controls?
Case-Control (n=42)
Can cardiac computed tomography-derived analysis of simultaneous LV and LA volume changes assess diastolic function in patients with hypertrophic cardiomyopathy compared to age-matched controls?
Absolute Event Rate: 30% vs 42%
p-value: p=<0.0001
Cardiac CT-derived simultaneous LV and LA volume changes can effectively characterize diastolic dysfunction in patients with hypertrophic cardiomyopathy.
CT-derived LA conduit changes may aid HCM diastolic assessment; hypothesis-generating, needs prospective validation before practice change.
OBJECTIVES: Hypertrophic cardiomyopathy (HCM) is characterized by diastolic dysfunction, which is difficult to assess by noninvasive methods. We hypothesized that measurement of simultaneous left ventricular (LV) and left atrial (LA) volume changes by cardiac computed tomography would be useful in the assessment of diastolic function in HCM. METHODS: We studied 21 patients with HCM and 21 age-matched controls. The LA and LV volumes were calculated and early and late diastolic volume changes derived. RESULTS: The HCM patients had significantly larger LA volumes and reduced LA total emptying fraction (30 ± 7% vs 42 ± 6%; P < 0.0001). Conduit volume was increased (30 ± 6 vs 22 ± 4 mL/m; P < 0.0001) and contributed a significantly higher proportion of total LV diastolic filling, suggesting that passive filling of the LV compensates for LA dysfunction, but at the expense of increased pulmonary filling pressure. CONCLUSIONS: This study suggests that simultaneous depiction of computed tomography-derived LV and LA volume changes can characterize diastolic dysfunction in HCM.
No takes yet. Share an insight, caveat, or question.
Ghersin et al. (2016) conducted a case-control in Hypertrophic cardiomyopathy (n=42). Hypertrophic cardiomyopathy vs. Age-matched controls was evaluated on Left atrial total emptying fraction (p=<0.0001). Hypertrophic cardiomyopathy was associated with significantly reduced left atrial total emptying fraction compared to controls (30% vs 42%; P<0.0001) as assessed by cardiac computed tomography.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: