Key result
Hypertrophic cardiomyopathy presents a complex clinical spectrum with heterogeneous patterns, symptoms, and risks of sudden cardiac death, posing a challenge for diagnosis and management.
Hypertrophic cardiomyopathy presents with a complex spectrum of phenotypes requiring tailored diagnosis and management to relieve symptoms and prevent sudden cardiac death.
HCM phenotypic heterogeneity challenges uniform risk assessment; leaves open need for phenotype-specific prospective validation before practice change.
The clinical spectrum of hypertrophic cardiomyopathy (HCM) is complex and includes a variety of phenotypes, which leads to different types of manifestations.Although most of the patients are asymptomatic, a significant proportion of them will develop symptoms or risk of arrhythmias and sudden cardiac death (SCD).Therefore, the objectives of HCM diagnosis and management are to relieve the patients' symptoms (chest pain, heart failure, syncope, palpitations, etc.), prevent disease progression and major cardiovascular complications and SCD.The heterogeneity of HCM patterns, their symptoms and assessment is a challenge for the cardiologist.
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A 2015 study conducted a review in Hypertrophic cardiomyopathy (HCM). Hypertrophic cardiomyopathy presents a complex clinical spectrum with heterogeneous patterns, symptoms, and risks of sudden cardiac death, posing a challenge for diagnosis and management.
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