Key result
Cardiomyocyte apoptosis publications rise steadily since 1996, led by heart failure and infarction research.
Why the study?
Research on cardiomyocyte apoptosis is fragmented, with few comprehensive analyses and systematic reviews.
This bibliometric review maps the growing academic focus on myocardial apoptosis, highlighting oxidative stress, inflammation, and clinical manifestations like heart failure and myocardial infarction as primary research hotspots.
Answers are grounded in this paper and cite their sources.
Rising apoptosis research in HF and MI; leaves open whether targeting oxidative stress or inflammation alters clinical outcomes.
BACKGROUND: Recent studies have found that cardiomyocyte apoptosis is closely associated with the pathophysiological development of various cardiovascular diseases, for example chronic heart failure and myocardial infarction. At present, there are many researches in this field, such as pharmacological research, traditional Chinese medicine intervention research and pathway research. However, the relevant research is fragmented, with few comprehensive analysis and systematic combing. METHODS: The relevant literature on cardiomyocyte apoptosis was downloaded from the Web of Science Core Collection (WoSCC) and PubMed databases. Citespace 6.1.R2 software Microsoft Excel 2019 and VOSviewer1.6.18.0 were used for bibliometric and visual analysis of publication volume, countries, institutions, journals, authors, keywords. RESULTS: Since 1996, there are 1881 research articles and reviews related to cardiomyocyte apoptosis published by 10,313 researchers from 1648 institutions in 58 countries or regions were included. The number of annual publications showed an upward trend, especially in recent years. Countries participating in this research area include China, the United States, and Japan. Capital Medical University, Harbin Medical University are the key research institution, and other institutions also have substantial contribution on the project as to cardiomyocyte apoptosis. The journal EUR REV MED PHARMACO has a large number of publications, whereas CIRCULATION has the highest number of co-citations. Keywords analysis showed that apoptosis, expression and oxidative stress had higher frequencies, leading to 8 clusters. CONCLUSIONS: Cardiomyocyte apoptosis is a hot research field in recent years. Through visualization and bibliometric analysis, it is found that this field focus on hotspots like clinical manifestations including heart failure or myocardial infarction, and microscopic mechanisms such as oxidative stress and inflammation.
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Lian et al. (2023) conducted a review in Cardiomyocyte apoptosis (n=1,881). Bibliometric and visual analysis was evaluated on Research trends and hotspots in myocardial apoptosis. Cardiomyocyte apoptosis research has shown an upward publication trend since 1996, with major research hotspots including heart failure, myocardial infarction, oxidative stress, and inflammation.
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