Key result
In 880 elderly individuals followed for 12 years, serum markers of collagen turnover (CITP and PIIINP) were significantly associated with myocardial infarction, incident heart failure, and death.
Why the study?
Do serum markers of collagen turnover (PIP, CITP, PIIINP) predict incident HF and cardiovascular outcomes in elderly individuals?
Population
880 participants in the Cardiovascular Health Study comprising 4 groups: HFrEF, HFpEF, control subjects with…
Design
Cohort
Follow-up
12±4 years (range, 3-17 years)
Authors
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Serum collagen markers may aid HF risk stratification in elderly adults; leaves open incremental value beyond clinical models in prospective studies.
Cohort (n=880)
Do serum markers of collagen turnover (PIP, CITP, PIIINP) predict incident HF and cardiovascular outcomes in elderly individuals?
Serum markers of collagen turnover, specifically CITP and PIIINP, are significantly associated with adverse cardiac outcomes including MI, HF, and death in elderly individuals.
Barasch et al. (2011) conducted a cohort in Elderly individuals at risk of or with heart failure (n=880). Serum markers of collagen turnover (PIP, CITP, PIIINP) was evaluated on Incident HF, cardiovascular morbidity, mortality, and all-cause mortality. In 880 elderly individuals followed for 12 years, serum markers of collagen turnover (CITP and PIIINP) were significantly associated with myocardial infarction, incident heart failure, and death.
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