Key result
In vivo studies using stable isotope tracers demonstrate that adipose tissue is a net importer of dietary fat for 5 hours following a single meal and for most of the day during a typical three-meal pattern, with impaired fatty acid trafficking observed in obesity.
Why the study?
How do natural and stable isotope tracers elucidate the metabolism of dietary fat and adipose tissue fatty acid trafficking in humans?
Population
Human subjects (including obese men) undergoing postprandial lipaemia studies
Design
Review
Authors
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Obesity impairs adipose fatty acid trafficking; leaves open interventional trials to test clinical relevance.
How do natural and stable isotope tracers elucidate the metabolism of dietary fat and adipose tissue fatty acid trafficking in humans?
In vivo studies using isotope tracers reveal that adipose tissue fatty acid trafficking, including 'spillover', significantly modulates postprandial plasma lipid concentrations, which is altered in obesity and after fructose ingestion.
Barbara A. Fielding (2011) conducted a review in Postprandial lipaemia. Dietary fatty acids was evaluated. In vivo studies using stable isotope tracers demonstrate that adipose tissue is a net importer of dietary fat for 5 hours following a single meal and for most of the day during a typical three-meal pattern, with impaired fatty acid trafficking observed in obesity.
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