June 27, 2021The Journal of Nutritional BiochemistryOpen Access

Postprandial plasma lipidome responses to a high-fat meal among healthy women

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Why the study?

Postprandial hypertriglyceridemia can alter HDL structure, function, and concentrations, which are linked to cardiovascular disease risk.

Does an acute high-fat meal alter the plasma lipidome composition in healthy young women?

Population

12 clinically healthy, nonobese and young women

Comparison

Plasma lipidome at fasting vs 1, 3, and 5 h after an acute high-fat meal

Follow-up

5 h

Authors

MYMarcos Y. YoshinagaUniversidade de São Paulo BQBruna Jardim QuintanilhaUniversidade de São Paulo ACAdriano B. Chaves‐FilhoGerman Cancer Research Center

Discussion

Member takes

Implication

Slow TG metabolizers show HDL TG/PI enrichment after high-fat meal; hypothesis-generating for postprandial CVD markers, needs larger validation.

Structured PICO

Does an acute high-fat meal alter the plasma lipidome composition in healthy young women?

Population

12 clinically healthy, nonobese, young women

Intervention

Acute high-caloric (1135 kcal) and high-fat (64 g) breakfast meal

Comparator

Fasting state (baseline)

Outcome

Plasma lipidome composition changes across fasting, 1, 3, and 5 hours postprandialsurrogate

Prolonged postprandial lipemia after a high-fat meal alters the HDL lipidome, particularly in slow triglyceride metabolizers, which may impact HDL function and cardiovascular risk.

Cite This Study

Yoshinaga et al. (2021) studied this question.

synapsesocial.com/papers/6a768ceec54884e1527d18b6 https://doi.org/10.1016/j.jnutbio.2021.108809

View Full Paper

Ask AI

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June 27, 2021The Journal of Nutritional BiochemistryOpen Access

Postprandial plasma lipidome responses to a high-fat meal among healthy women

View Full Paper

Ask AI

Bookmark

Why the study?

Postprandial hypertriglyceridemia can alter HDL structure, function, and concentrations, which are linked to cardiovascular disease risk.

Does an acute high-fat meal alter the plasma lipidome composition in healthy young women?

Population

12 clinically healthy, nonobese and young women

Comparison

Plasma lipidome at fasting vs 1, 3, and 5 h after an acute high-fat meal

Follow-up

5 h

Authors

MYMarcos Y. YoshinagaUniversidade de São Paulo BQBruna Jardim QuintanilhaUniversidade de São Paulo ACAdriano B. Chaves‐FilhoGerman Cancer Research Center

Discussion

Member takes

Implication

Slow TG metabolizers show HDL TG/PI enrichment after high-fat meal; hypothesis-generating for postprandial CVD markers, needs larger validation.

Structured PICO

Does an acute high-fat meal alter the plasma lipidome composition in healthy young women?

Population

12 clinically healthy, nonobese, young women

Intervention

Acute high-caloric (1135 kcal) and high-fat (64 g) breakfast meal

Comparator

Fasting state (baseline)

Outcome

Plasma lipidome composition changes across fasting, 1, 3, and 5 hours postprandialsurrogate

Prolonged postprandial lipemia after a high-fat meal alters the HDL lipidome, particularly in slow triglyceride metabolizers, which may impact HDL function and cardiovascular risk.

Cite This Study

Yoshinaga et al. (2021) studied this question.

synapsesocial.com/papers/6a768ceec54884e1527d18b6 https://doi.org/10.1016/j.jnutbio.2021.108809

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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