Key result
Oral lipid load drives peak triglycerides to ~221 mg/dl at 5 hours in healthy men.
Why the study?
Postprandial changes of triglycerides in lipoprotein fractions and their relation to insulin response in healthy normal-weight individuals with normal fasting triglycerides were not well characterized.
Does a standardized oral lipid load reveal exaggerated postprandial triglyceride and altered insulin responses in healthy normal-weight humans?
Population
13 healthy male nonsmokers with normal fasting triglycerides
Comparison
Postprandial triglyceride and insulin responses after standardized oral lipid load
Design
Observational study
Follow-up
5 hours
Authors
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Postprandial triglyceride responses vary markedly even among healthy young men; leaves open the determinants of individual lipid excursions and their clinical relevance.
Observational (n=13)
Does a standardized oral lipid load reveal exaggerated postprandial triglyceride and altered insulin responses in healthy normal-weight humans?
p-value: p=<0.001
An exaggerated postprandial triglyceride response to an oral lipid load may indicate increased atherogenic risk in some healthy individuals with normal fasting triglycerides.
Schrezenmeir et al. (1992) conducted an observational in Healthy (n=13). Standardized oral lipid load vs. Fasting state was evaluated on Peak total triglycerides (p=<0.001). A standardized oral lipid load significantly increased total triglycerides to a peak value of 221 +/- 81 mg/dl at 5 hours (p < 0.001) in healthy male nonsmokers.
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