November 1, 1995Arteriosclerosis Thrombosis and Vascular Biology
Association of Postprandial Triglyceride and Retinyl Palmitate Responses With Newly Diagnosed Exercise-Induced Myocardial Ischemia in Middle-Aged Men and Women
Why the study?
Are postprandial triglyceride and retinyl palmitate responses associated with newly diagnosed exercise-induced myocardial ischemia in middle-aged men and women?
Population
205 middle-aged adults without prior diagnosis of CAD undergoing diagnostic exercise electrocardiographic or…
Comparison
Postprandial triglyceride and retinyl palmitate… vs Control subjects with negative stress tests.
Design
Case-control
Authors
Discussion
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Implication
Does not support postprandial testing for ischemia risk; hypothesis-generating for sex- and BMI-specific atherogenicity.
Structured PICO
Are postprandial triglyceride and retinyl palmitate responses associated with newly diagnosed exercise-induced myocardial ischemia in middle-aged men and women?
P
Population
205 middle-aged adults (92 men, 113 women; mean age 51.6 and 53.6 years, respectively) without prior diagnosis of CAD undergoing diagnostic exercise electrocardiographic or thallium stress tests.
I
Intervention
Postprandial triglyceride (TG) and retinyl palmitate (RP) responses measured 2, 3.5, 5, and 8 hours after consuming a fatty test meal.
C
Comparator
Control subjects with negative stress tests (no exercise-induced myocardial ischemia).
O
Outcome
Newly diagnosed exercise-induced myocardial ischemia (EIMI) on diagnostic exercise electrocardiographic or thallium stress tests.surrogate
Postprandial triglyceride and retinyl palmitate responses are independently associated with exercise-induced myocardial ischemia in non-obese middle-aged men, suggesting postprandial lipemia may be atherogenic in this subgroup.
Limitations
- Cross-sectional/case-control design indicates the need for a prospective study
Cite This Study
Ginsberg et al. (1995) studied this question.