Association of Postprandial Triglyceride and Retinyl Palmitate Responses With Asymptomatic Carotid Artery Atherosclerosis in Middle-aged Men and Women
Why the study?
Are postprandial triglyceride and retinyl palmitate responses associated with asymptomatic carotid artery atherosclerosis in middle-aged men and women?
Population
602 middle-aged men and women, comprising 229 cases with asymptomatic carotid artery atherosclerosis and 373…
Comparison
Fatty meal with vitamin A, followed by 3.5- and… vs Control subjects free of atherosclerosis.
Design
Case-control
Authors
Discussion
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Member takes
Implication
May identify residual atherosclerotic risk beyond fasting lipids in nonobese whites; hypothesis-generating and should not yet change practice.
Structured PICO
Are postprandial triglyceride and retinyl palmitate responses associated with asymptomatic carotid artery atherosclerosis in middle-aged men and women?
P
Population
602 middle-aged men and women, comprising 229 cases with asymptomatic carotid artery atherosclerosis (defined by carotid intima-media thickness on ultrasound) and 373 control subjects free of atherosclerosis.
I
Intervention
Fatty meal with vitamin A, followed by 3.5- and 8-hour measurements of triglycerides (TGs), TG-rich lipoprotein TGs, apoproteinB48, and retinyl palmitate.
C
Comparator
Control subjects free of atherosclerosis.
O
Outcome
Association of postprandial lipid responses with asymptomatic carotid artery atherosclerosis case status.surrogate
Elevated postprandial triglycerides appear to be an independent risk factor for carotid intimal thickening in nonobese white individuals, independent of fasting lipid levels.
Cite This Study
Sharrett et al. (1995) studied this question.