Postprandial lipemia and the risk of coronary heart disease and stroke: the Atherosclerosis Risk in Communities (ARIC) Study
Key result
Standardized measures of postprandial lipemia, including postprandial triglycerides, were not significantly associated with incident coronary heart disease or stroke over 20 years of follow-up (HR 0.95).
Why the study?
Does the degree of postprandial lipemia predict incident cardiovascular disease in a middle-aged population without baseline CVD?
Population
n=559 middle-aged, biracial participants without cardiovascular disease from the community-based…
Design
Cohort
Follow-up
over more than 20 years
Authors
Discussion
Loading...
Member takes
Implication
No independent PPL-CVD link in this cohort; leaves open whether standardised postprandial measures add prognostic value beyond fasting lipids in larger studies.
Study Design
Type
Cohort (n=559)
Multicenter
Yes
Structured PICO
Does the degree of postprandial lipemia predict incident cardiovascular disease in a middle-aged population without baseline CVD?
P
Population
559 middle-aged adults without baseline cardiovascular disease from the ARIC cohort, followed for a median of 20.5 years to assess the association of postprandial lipemia with incident cardiovascular events.
E
Exposure
Standardised fat challenge to measure postprandial lipemia (postprandial triglycerides, TG-rich lipoprotein triglycerides, retinyl palmitate and apolipoprotein B48 to B100 ratio)
O
Outcome
Incident cardiovascular disease events (coronary heart disease, stroke)hard clinical
Main Result
Hazard Ratio: 0.95 (95% CI 0.8–1.13)
p-value: p=0.557
Standardized measures of postprandial lipemia did not predict excess cardiovascular disease risk over 20 years of follow-up in a community-based cohort.
Limitations
- Low statistical power due to small sample size
- Potential for residual confounding despite adjustment for known cardiovascular risk factors
- Sample size may be underpowered
Cite This Study
Kats et al. (2017) conducted a cohort in Cardiovascular disease (n=559). Postprandial lipemia (1-unit increase in iAUC-transformed weighted SD of postprandial triglycerides) vs. Lower levels of postprandial triglycerides was evaluated on Incident coronary heart disease or stroke (HR 0.95, 95% CI 0.80-1.13, p=0.557). Standardized measures of postprandial lipemia, including postprandial triglycerides, were not significantly associated with incident coronary heart disease or stroke over 20 years of follow-up (HR 0.95).