Key result
A newly designed oral fat-loading test containing 31.6 g of fat significantly elevated serum triglycerides and remnant-like particle-cholesterol levels at 2 to 4 hours post-ingestion (p<0.01).
Why the study?
Does a newly designed oral fat-loading test effectively estimate postprandial hypertriglyceridemia and remnant concentrations in healthy volunteers?
Population
23 healthy normolipidemic volunteers, mean age 24.0, 15 male / 8 female, based in Japan.
Comparison
Oral fat-loading test meal consisting of a… vs Baseline measurements before the meal.
Design
Cohort
Follow-up
9 hours
Authors
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Supports feasibility of simple oral fat challenge for postprandial assessment in volunteers; leaves open validation and clinical utility.
Observational (n=23)
No
Does a newly designed oral fat-loading test effectively estimate postprandial hypertriglyceridemia and remnant concentrations in healthy volunteers?
Absolute Event Rate: 134% vs 81.6%
p-value: p=<0.01
A newly designed, simple oral fat-loading test using an enteral nutrition drink and butter effectively induces and measures postprandial hypertriglyceridemia and remnant-like particle-cholesterol without gastrointestinal side effects.
Igarashi et al. (2003) conducted an observational in Healthy normolipidemic (n=23). Oral fat-loading test meal (Telmeal 2.0 and salt-free butter) vs. Baseline (fasting state) was evaluated on Serum triglycerides at 2 hours post fat-loading (p=<0.01). A newly designed oral fat-loading test containing 31.6 g of fat significantly elevated serum triglycerides and remnant-like particle-cholesterol levels at 2 to 4 hours post-ingestion (p<0.01).
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