Key result
End-stage renal disease patients exhibited significantly higher within-subject biological variation of serum cardiac troponin T (14.7%) compared to healthy individuals (5.9%).
Why the study?
What is the biological variation of high-sensitivity cardiac troponin T in patients with end-stage renal disease compared to healthy individuals?
Observational (n=29)
What is the biological variation of high-sensitivity cardiac troponin T in patients with end-stage renal disease compared to healthy individuals?
Absolute Event Rate: 14.7% vs 5.9%
Biological variation of cardiac troponin T is significantly higher in ESRD patients than in healthy individuals, requiring specific reference change values (44.1% two-tailed) to accurately diagnose acute cardiovascular events.
No takes yet. Share an insight, caveat, or question.
Standard reference change values may not apply in ESRD; leaves open whether ESRD-specific thresholds improve acute event diagnosis.
Corte et al. (2014) conducted an observational in End-stage renal disease (n=29). End-stage renal disease vs. Healthy individuals was evaluated on Within-subject coefficient of variation (CVI) of serum cardiac troponin T. End-stage renal disease patients exhibited significantly higher within-subject biological variation of serum cardiac troponin T (14.7%) compared to healthy individuals (5.9%).
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