Key result
In patients with moderate chronic kidney disease, reference change values for increasing and decreasing concentrations were +60%/-38% for cardiac troponin I and +25%/-20% for cardiac troponin T.
Why the study?
Patients with chronic kidney disease often have elevated troponins without myocardial infarction, making NSTEMI diagnosis challenging. The study aimed to calculate the biological variation of cardiac troponin I and T in moderate chronic kidney disease to improve interpretation of serial measurements.
Observational (n=20)
In patients with moderate CKD, the reference change value for cardiac troponin T is ~20-25%, aligning with NACB guidelines, whereas cardiac troponin I requires much larger changes (+60%/-38%) to indicate a true biological change.
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Separate RCVs for cTnI (+60%/–38%) versus cTnT (+25%/–20%) may refine serial interpretation in moderate CKD; leaves open validation for NSTEMI diagnosis.
Jones et al. (2020) conducted an observational in moderate chronic kidney disease (n=20). Serial cardiac troponin measurements was evaluated on biological variation and reference change values for cardiac troponin I and T. In patients with moderate chronic kidney disease, reference change values for increasing and decreasing concentrations were +60%/-38% for cardiac troponin I and +25%/-20% for cardiac troponin T.
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