Four pairs of oxygenated terpenes, with closely related chemical structures but considerably different minimum inhibitory concentration values (1) against P. aeruginosa or E. coli, showed differences in rate of cells killed over 2 h. Addition of polymyxin B nonapeptide (PMBN) as an outer membrane permeabilising agent was found to significantly increase the initial rates and overall numbers of cells killed for all compounds. The hydrocarbon limonene and the ester geranyl acetate, normally inactive, were also investigated. Both compounds had little killing effect when added alone to the cells but did show an enhanced killing capacity upon the addition of PBMN.
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Griffin et al. (2001) studied this question.
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