The Mechanisms Responsible for Lack of Reproducible Induction of Atrioventricular Nodal Reentrant Tachycardia
Key result
AVNRT induction is poorly reproducible in approximately 10% of patients, most commonly due to fast pathway block (49%) in the baseline state (P=0.02).
Why the study?
What are the mechanisms responsible for the lack of reproducible induction of AVNRT in patients undergoing electrophysiological study?
Population
103 patients with atrioventricular nodal reentrant tachycardia (AVNRT)
Design
Cohort
Authors
Discussion
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Implication
Fast pathway block predominates in baseline AVNRT noninducibility; hypothesis-generating for mechanism-specific ablation pending prospective confirmation.
Study Design
Type
Observational (n=103)
Structured PICO
What are the mechanisms responsible for the lack of reproducible induction of AVNRT in patients undergoing electrophysiological study?
P
Population
103 patients with AV nodal reentrant tachycardia undergoing electrophysiological stimulation to assess reproducibility of induction.
E
Exposure
Atrial burst pacing, and atrial and ventricular programmed stimulation (with one and two extrastimuli), repeated 10 times in baseline state, during isoproterenol infusion, and after atropine administration
O
Outcome
Mechanisms responsible for < 7 of 10 inductions of AVNRT (classified as inability to achieve critical AH prolongation, fast pathway block, or slow pathway block)surrogate
Main Result
p-value: p=0.02
Fast pathway block is the most common reason for the inability to reproducibly induce AVNRT in the baseline state, whereas during isoproterenol or atropine administration, multiple mechanisms contribute equally.
Cite This Study
Strickberger et al. (1996) conducted an observational in AV nodal reentrant tachycardia (AVNRT) (n=103). Electrophysiological stimulation was evaluated on Mechanisms responsible for lack of reproducible induction of AVNRT (< 7 of 10 inductions) (p=0.02). AVNRT induction is poorly reproducible in approximately 10% of patients, most commonly due to fast pathway block (49%) in the baseline state (P=0.02).