Key result
MitraClip resolves severe degenerative MR and cuts LVOT gradient by ~43 mmHg in HOCM.
Why the study?
Does the MitraClip system successfully treat both degenerative MR and SAM from HOCM in a single procedure in a high-risk patient?
Case Report (n=1)
Does the MitraClip system successfully treat both degenerative MR and SAM from HOCM in a single procedure in a high-risk patient?
The MitraClip system can be feasibly used to simultaneously treat severe degenerative MR and systolic anterior motion from HOCM in high-risk patients.
Hypothesis-generating for MitraClip in combined degenerative MR and obstructive HOCM; requires prospective validation before clinical adoption.
BACKGROUND: The MitraClip system has been used extensively in high-risk patients with severe degenerative mitral regurgitation (MR). Recent reports have demonstrated the feasibility of using the MitraClip device to treat systolic anterior motion (SAM) of the mitral valve in obstructive hypertrophic cardiomyopathy (HOCM). CASE SUMMARY: We report the case of a 76-year-old lady who had both symptomatic severe degenerative MR and HOCM that were refractory to medical therapy. Both pathologies were treated successfully using the MitraClip system. DISCUSSION: In patients who are deemed to be at high risk for open surgery, our case demonstrated the feasibility of a percutaneous avenue, the MitraClip system, to treat not just degenerative MR, but also SAM from HOCM in a single procedure.
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Wong et al. (2018) conducted a case report in Severe degenerative mitral regurgitation and obstructive hypertrophic cardiomyopathy (HOCM) (n=1). MitraClip was evaluated on Mitral regurgitation grade and left ventricular outflow tract (LVOT) gradient. The MitraClip system successfully treated both severe degenerative mitral regurgitation and systolic anterior motion from obstructive hypertrophic cardiomyopathy in a single procedure, reducing MR to grade 1-2+ and the LVOT gradient from 76 mmHg to 33 mmHg.
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